Research Articles
CAP IHC Validation Guidelines 2024: A Step-by-Step Protocol for Assay Qualification and Compliance
This comprehensive guide details the College of American Pathologists (CAP) guidelines for immunohistochemistry (IHC) control validation, providing researchers, scientists, and drug development professionals with the essential framework to ensure assay...
CAP IHC Validation Guidelines 2024: A Complete Guide to Assay Development, Optimization, and Compliance
This article provides a comprehensive analysis of the 2024 CAP guideline update for immunohistochemistry (IHC) assay validation.
A Practical Guide to CAP IHC Validation Guidelines: Achieving CLIA Compliance for Precision Medicine
This comprehensive guide demystifies the College of American Pathologists (CAP) guidelines for the analytic validation of immunohistochemistry (IHC) assays within a CLIA-certified laboratory framework.
From Scurfy Mice to Clinical Breakthroughs: How FoxP3 Discovery Revolutionized Autoimmunity and Immunotherapy Research
This article provides a comprehensive analysis of the seminal discovery of FoxP3 through the study of the Brunkow and Ramsdell scurfy mouse mutant.
Bouin's Fixative: A Complete Guide for Superior Preservation of Delicate Tissues
This comprehensive guide explores Bouin's fixative for researchers working with delicate tissues.
The Essential Guide to Blocking Non-Specific Binding: Optimizing IHC and ICC Protocols for Clear, Reproducible Results
Non-specific binding (NSB) is a critical, yet often overlooked, factor that can compromise the accuracy, signal-to-noise ratio, and reproducibility of immunohistochemistry (IHC) and immunocytochemistry (ICC) experiments.
Effective Biotin Blocking in IHC: Complete Guide to Background Reduction and Signal Optimization
This comprehensive guide addresses the critical challenge of endogenous biotin interference in immunohistochemistry (IHC).
ELISA Blocking Battle: BSA vs. Casein – A Comprehensive Guide for Optimal Assay Performance
This article provides a detailed comparative analysis of Bovine Serum Albumin (BSA) and casein as blocking agents in ELISA.
BE70 vs Formalin: A Comprehensive Guide for RNA Integrity in Modern Research and Diagnostics
This article provides a detailed, evidence-based comparison of BE70 (ethanol-based) and formalin fixation methods for preserving RNA integrity.
The BE70 Protocol: A Superior Tissue Fixation Method for High-Quality RNA Preservation in Research
This article provides a comprehensive guide to the BE70 (buffered 70% ethanol) tissue fixation protocol, a critical methodology for preserving RNA integrity in biobanked and diagnostic samples.